Cancer Prev. Res.,12(8) 527-538 (2019)
Patients with inflammatory bowel disease (IBD) colitis are at an increased risk of developing colorectal cancer and are currently recommended to undergo extensive annual or biennial colonoscopy, a costly and invasive procedure. Most surveillance colonoscopies are negative with no existing objective measures for assessing their risk of developing cancer. Our paper extends the less invasive, cost-effective and objective nanoscale nuclear architecture mapping (nanoNAM) method - a derivative of Fourier-domain Optical Coherence Tomography - to three dimensions (3D) , and applies it to detecting colorectal neoplasia in patients with inflammatory bowel disease from normal-appearing rectal biopsies.
Featured on the cover of the August 1, 2019 issue of Cancer Prevention Research (AACR).
