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July 24, 2018
Publication

Super-resolution imaging of higher-order chromatin structures at different epigenetic states in single mammalian cells

J. Xu, H. Ma, J. Jin, S. Uttam, R. Fu, Y. Huang, and Y. Liu

Cell Reports; 24(4): 873-882 (2018).

As a part of this work, we developed a nuclei segmentation method for stochastic optical reconstruction microscopy that avoids segmentation getting stuck in local minima due to numerous and distinct chromatin clusters within the nuclei reconstructed using localization microscopy.

https://doi.org/10.1016/j.celrep.2018.06.085