Am. J. Physiol. Gastrointest. Liver Physiol. 320(3):G396-G410
This study presents the development of a pre-clinical ex vivo system for testing efficacy and target engagement of therapeutics in inflammatory bowel disease using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis. Tofacitinib based JAK/STAT signaling inhibition was used to test the system. We performed the computational and statistical analyses.
