Carli Newman is a Senior at Reed College, Portland, OR. After having successfully completing the summer REU program (TECBio) in the lab, here at University of Pittsburgh, she will continue to work on her research project as part of her Senior year thesis.

Rajdeep is an MS student in the Department of Computational Biology at Carnegie Mellon University. He will doing his MS thesis work in the lab.

We will be giving a talk at the 2022 Annual Meeting of Biomedical Engineering Society (BMES) on spatial analysis of cytotoxic T lymphocyte infiltration in colorectal tumors for predicting stage-independent relapse and death.

We will be presenting our results on predicting neoplastic progression in patients with Barrett's Esophagus. This was joint work with Dr. Yang Liu in the Dept. of Medicine at Pitt, and with Dr. Prashanthi Thota and Dr. Xuefeng Zhang  at Cleveland Clinic.

We will also be presenting our initial results on profiling immune microenvironment of patients with Lynch Syndrome. This was joint work with Dr. Rhonda M. Brand and Dr. Randall E Brand in the Dept. of Medicine at Pitt.

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DDW 2022

May 21-24, 2022, San Diego, CA, United States.

We will present our new results on unsupervised segmentation of tissue samples at 2022 AACR Annual Meeting

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2022 AACR Annual Meeting

April 8-13, 2022, Ernest N. Morial Convention Center, New Orleans, Louisiana, United States.

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Gastrointestinal Endoscopy; 95(6):1239-1246 (2022).

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We utilized the ability of nanoscale nuclear architecture mapping (nanoNAM) to detect with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation, to identify patients with Barrett’s esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

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Biomedical Engineering Society (BMES) 2021 Annual Meeting (Oct 6 - 9, 2021; Orlando, Florida). Abstract 074 - 841, BMES 2021 Annual Meeting.

We present our preliminary results on a new unsupervised  method we are developing for segmenting complex tissue samples in highly multiplexed immunofluorescence images.

Biomedical Engineering Society (BMES) 2021 Annual Meeting (Oct 6 - 9, 2021; Orlando, Florida). Abstract reu-011-3129, BMES 2021 Annual Meeting.

We present our updated results on computational modeling of nanoscale nuclear architecture mapping of epithelial cells undergoing malignant transformation and show recent results on them capturing underlying chromatin reorganization.