Gastrointestinal Endoscopy; 95(6):1239-1246 (2022).

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We utilized the ability of nanoscale nuclear architecture mapping (nanoNAM) to detect with nanoscale sensitivity, structural alterations in the chromatin of epithelial cell nuclei at risk for malignant transformation, to identify patients with Barrett’s esophagus (BE) who progress to high grade dysplasia (HGD) or esophageal adenocarcinoma (EAC).

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Biomedical Engineering Society (BMES) 2021 Annual Meeting (Oct 6 - 9, 2021; Orlando, Florida). Abstract reu-007-3147, BMES 2021 Annual Meeting.

We present some preliminary results on a method to analyze assays such as multiplexed enzyme-linked immunosorbent (ELISA) assay to identify analytes whose expression are not meaningful and should be removed from further analysis.

Biomedical Engineering Society (BMES) 2021 Annual Meeting (Oct 6 - 9, 2021; Orlando, Florida). Abstract reu-011-3129, BMES 2021 Annual Meeting.

We present our updated results on computational modeling of nanoscale nuclear architecture mapping of epithelial cells undergoing malignant transformation and show recent results on them capturing underlying chromatin reorganization.

Biomedical Engineering Society (BMES) 2021 Annual Meeting (Oct 6 - 9, 2021; Orlando, Florida). Abstract 074 - 841, BMES 2021 Annual Meeting.

We present our preliminary results on a new unsupervised  method we are developing for segmenting complex tissue samples in highly multiplexed immunofluorescence images.

United States Patent 11,105,686 on spatial-domain low-coherence quantitative phase microscopy was granted to us. I am one of the co-inventors.

We were awarded the University of Pittsburgh Clinical and Translational Science Institute (CTSI) Biomedical Modeling Pilot award for studying intra-tumor heterogeneity of colorectal cancer tumor microenvironment.

Am. J. Physiol. Gastrointest. Liver Physiol. 320(3):G396-G410

This study presents the development of a pre-clinical ex vivo system for testing efficacy and target engagement of therapeutics in inflammatory bowel disease using freshly obtained and well-characterized human colorectal tissue from patients with ulcerative colitis. Tofacitinib based JAK/STAT signaling inhibition was used to test the system. We performed the computational and statistical analyses.

Proc. SPIE 11653, Quantitative Phase Imaging VII, 1165318 (5 March 2021)

We present our results on computational modeling of nanoscale nuclear architecture mapping of epithelial cells undergoing malignant transformation and show preliminary results on them capturing underlying chromatin reorganization.